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Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access 199,00 per year only 3,83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature 629 , 1011-1012 (2024) doi: References Petersen, J

The spectrum ranges from simple steatosis (fat accumulation without significant inflammation) to nonalcoholic steatohepatitis (NASH), which involves inflammation and hepatocyte injury that can progress to fibrosis, cirrhosis, and hepatocellular carcinoma

Background Obesity is a chronic metabolic disease characterized by excessive accumulation of body fat

Studies involving female cohorts were considered when relevant for mechanistic insights but were not used to extrapolate clinical conclusions regarding TRT

It also appears unlikely that GLP1 receptormediated effects on cell survival via ERK1/2 signalling can be clearly separated from activation of cAMP/PKA pathways, not least as ERK1/2 phosphorylation is partly PKA dependent