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Rosenbaum notes

In this work, we present four pre-clinical studies and a proof-of-concept clinical trial that address this issue

Alkhouri N, Herring R, Kabler H, Kayali Z, Hassanein T, Kohli A, et al

Figure 2 Exenatide, a peptide of 39 amino acids, has a much slower metabolism than endogenous GLP-1 (half-life of 3-4 h) (119, 120)

In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]

Furthermore, this targeting principle requires additional validation, particularly in the context of human biology, before tangible conclusions regarding its applicability to clinical pharmacology can be made