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It's hepatic fat being mobilized, hepatic glycogen being depleted, intramuscular triglyceride disappearing, extracellular fluid shifting

They have different mechanisms and indications

GLP-1 RAs work by mimicking the actions of the naturally occurring hormone GLP-1

GLP-1 reduces the migration of hepatocellular carcinoma cells via suppression of the stress-activated protein kinase/c-Jun N-terminal kinase pathway

122 Two PCOS mouse models were developed using prenatal androgenization (via DHT administration to pregnant dams on gestational days 1618) and postweaning androgenization (via subcutaneous DHT implants at day 21), followed by high-fat diet exposure and 28-day treatment with GLP-1-based mono- and multi-agonists or metformin starting on postnatal day 80, with outcomes assessed at day 108

When discontinuing GLP-1 medications, food noise is likely to return, and is theorized to be one of the key reasons for weight regain