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Yet cardiomyocytes, the main muscle cells of the heart, and hepatocytes in the liver do not appear to express GLP-1 or GIP receptors in significant amounts

Therapeutic Advances in Endocrinology and Metabolism

Your eating pattern and blood sugar are changing, and your body is doing extra work to adapt

Immunohistochemical staining and western blot analysis revealed that SNL increased the activation of microglia and astrocytes in the dentate gyrus of the hippocampus, along with elevated expression of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which were significantly reversed by exendin-4 treatment [68]

doi: 10.1056/NEJMoa2028198

This is consistent with RPc-evoked cardiac protection being blocked by glibenclamide in vivo 17 and with GLP-1 activating K ATP channels in smooth muscle cells 18 and pancreatic beta cells 19
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