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Increase gradually over 2 to 3 weeks

Some patients, termed super-responders, lose more weight than expected

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These medicines were originally developed to manage type 2 diabetes but have gained recognition for their broader metabolic benefits

Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent