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These agents are derived from either exendin or human GLP-1 and are designed to have enhanced enzymatic stability against dipeptidyl peptidase 4 (DPP-4), along with slower elimination kinetics compared to native GLP-1

Clinical trial data strongly suggests retatrutide produces significantly greater weight loss

doi: 10.2337/dc14-1942

At Genesis Lifestyle Medicine in Fort Collins, CO, this approach is incorporated into a provider-guided program designed to support lasting weight management and meaningful lifestyle changes

30,31 The association between the benefits of metabolic surgery and increased secretion of gut hormones such as glucagon-like peptide (GLP)-1 has led to the development of a class of drugs active in both obesity and T2D