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Ozempic is FDA-approved for specified type 2 diabetes and cardiovascular-risk indications, not for weight management

It is important to discuss the potential risks and benefits of these medications with your healthcare provider before starting treatment

Trial participant reports While not systematic data, reports from TRIUMPH trial participants provide additional context: Evidence: Community-reported One TRIUMPH-1 participant reported losing 30.6% of body weight (approximately 75 pounds) after one year on the trial, going from XL/2XL shirts to medium and fitting into size 32 pants for the first time in 20 years The same participant reported cholesterol down 30-33%, triglycerides down 70%, blood pressure normalized, fatty liver disease resolved (confirmed by CT scan), and asthma symptoms eliminated These individual results are consistent with the upper range of clinical trial outcomes and should not be taken as typical Beyond Weight Loss: Other Results TRIUMPH-4 measured outcomes beyond the scale: Cardiovascular markers Knee osteoarthritis outcomes (TRIUMPH-4 specific) Liver fat (Phase 2 sub-study) A sub-study of the Phase 2 trial measured liver fat by MRI and found reductions of up to 82.4% at the highest dose among the strongest liver fat reduction results for any drug in development

Metabolically, turmeric's anti-inflammatory action may complement semaglutide's weight loss mechanism by reducing systemic inflammation that often accompanies obesity

That means that more research will be needed to find out for certain if semaglutide does have benefits to reduce cognitive dysfunction or affect smoking rates in people with diabetes, John Wilding, a professor of medicine at the University of Liverpool who reviewed the study independently, said in a comment distributed by the nonprofit Science Media Centre

doi: 10.1016/j.copsyc.2015.03.004 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Sumithran P, Prendergast LA, Delbridge E, et al