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Regarding secondary effects of GLP-1 RAs, anti-inflammatory benefits emerge as the biochemical pathways are elucidated

Despite their markedly greater effects on blood glucose lowering, neither exendinphe1 nor P5 showed any increases in anorectic efficacy compared to exendin4 (Jones, Bloom, et al., 2018

doi: 10.1097/ALN.0000000000000320 21 JiaYGongNLiTFZhuBWangYX

IP or VTA injection of Ex-4 decreased ghrelin-induced food intake (Howell et al., 2019)

Darshan Shah, MD, board-certified surgeon, published author, and co-founder of NEXT|HEALTH, the fastest-growing health optimization and longevity clinic network

Combination with SGLT2 inhibitors to augment the benefits of this drug class in HFrEF with, for example, the weight-lowering effects of GLP-1 RA could offer a clinically valuable and feasible option addressing the spectrum of abnormalities associated with this HF phenotype