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Mansur SA, Mieczkowska A, Flatt PR, Chappard D, Irwin N, Mabilleau G

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Additional insights come from the phase 3 STEP trial (STEP 3), which combined 2.4 mg semaglutide with an intensive low-calorie diet (10001200 kcal/day meal replacements for the first 8 weeks, followed by a hypocaloric diet of 12001800 kcal/day) and progressive increases in physical activity to 200 minutes per week [13]

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It involves many complex mechanisms