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Description
Frequently Asked Questions As of July 2026, retatrutide has completed four Phase 3 readouts: TRIUMPH-4 (28.7% weight loss in knee OA population, December 2025), TRIUMPH-1 (28.3% weight loss in 2,339 general obesity patients, May 2026), TRANSCEND-T2D-1 (-2.0% HbA1c and 16.8% weight loss in 537 T2D patients, June 2026), and the TRIUMPH-1 sleep apnea substudy (60.6% AHI reduction, June 2026)

Hard feces Only one trial was evaluated regarding the risk of hard feces in patients receiving GLP-1 RAs

Cagrilintide Cagrilintide is an investigational amylin receptor agonist developed for the treatment of obesity and weight management

Safety and efficacy of liraglutide on reducing visceral and ectopic fat in adults with or without type 2 diabetes mellitus: A systematic review and meta-analysis

This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity. Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications

TMates accepts most major insurance plans, including Aetna, Cigna, UnitedHealthcare, and Blue Cross Blue Shield
