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They upregulate the expression and activity of key antioxidant enzymes, including manganese superoxide dismutase (MnSOD), catalase, and glutathione peroxidase-1 (GPx-1), through activation of the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway [44]

For example, efpeglenatide, a long-acting GLP-1 RA and an exendin analog linked to an IgG4 Fc fragment, has been explored for once-monthly administration to treat type 2 diabetes.197,198 Additionally, efforts have been made to develop oral formulations with improved bioavailability ( F )

Some individuals are genetically predisposed to robust GLP-1 signaling, while others show blunted responses

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N Engl J Med 391: 299310