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More frequent monitoring may be needed with oral semaglutide due to the known pharmacokinetic interaction that increases levothyroxine exposure by approximately 33%

173,174 Collectively, these mechanisms of action make GLP-1 RAs an important therapeutic agent for the treatment of IR and for improving glycemic control

Their comparison illustrates the two dominant strategies in modern obesity pharmacotherapy: combination therapy with proven agents versus novel single-molecule multi-agonism

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