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38 , 40 , 41 , 42 , 43 In contrast, STEP 2 had a lower proportion of female participants (51% vs

Here are some general considerations that healthcare providers may take into account when helping patients decide between these two medications: Weight Loss Goals: Some patients may require more aggressive weight loss strategies, while others may benefit from a more gradual approach

However, tirzepatide (dual GLP-1/GIP agonist) demonstrated even greater results in the SURMOUNT-1 trial, with 1520% body weight reduction at higher doses, making it currently the most powerful option available

The difference is whether you account for it in your experimental design or discover it retroactively when results stop making sense

Store lyophilised at -20 C in a sealed, desiccant-protected vial

Publication bias was evaluated visually through funnel plots and formally using Eggers test