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48 In the Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) trial in adult participants with obesity but without T2DM, tirzepatide (10 mg or 15 mg) achieved greater weight loss compared with semaglutide (1.7 mg or 2.4 mg weekly dose): 20.2% (95% CI 21.4 to 19.1) versus -13.7% (95% CI 14.9 to 12.6) at week 72

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Adults receiving an SGLT2 inhibitor also had a lower risk for an adverse safety outcome than the GLP-1 receptor agonist group (HR = 0.91

Weight Loss Surgery Isnt surgery riskier than weight loss injections? Surgery does carry risks, but modern bariatric procedures have safety profiles comparable to many commonly performed surgeries (e.g

The mechanism of action involves several pathways: Appetite regulation : Semaglutide acts on receptors in the brain (particularly in the hypothalamus) to reduce hunger and increase feelings of fullness, leading to decreased calorie intake

The drug works by activating mu-opioid receptors in the brain