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Short-term GLP-1 therapy can jumpstart weight loss, but individual outcomes depend on dose escalation, metabolic factors, and treatment adherence

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After many requests from readers, we decided to compare the two side-by-side...

this supports the hypothesis that the cardioprotective benefits of GLP-1RA and SGLT2i may be additive

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Conclusion The current evidence suggests a possible association between use of GLP-1RA and an increased risk of depression, but overall risk seems to be dominated by population characteristics, drug class, and how mood outcomes are assessed