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The popularity led to sky-high prices, supply shortages and, in some cases, desperate measures by those seeking to lose weight

"Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis"

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This is why Mounjaro is introduced gradually, starting with a lower dose to help reduce the intensity and duration of symptoms