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SELECT Trial The SELECT trial, one of the largest cardiovascular outcomes trials in obesity medicine, enrolled over 17,000 participants with established cardiovascular disease and obesity or overweight (without diabetes) and demonstrated a 20% reduction in MACE with semaglutide 2.4 mg

However, individual responses vary considerably, and the appetite-suppressing effects may not be uniform across all patients or throughout the treatment course

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Proper injection technique and site selection are essential foundations of effective semaglutide therapy