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GLP-1 medications are a game changer for weight loss, but have serious health concerns

Once opened, compounded semaglutide typically lasts 28 days in the fridge

Retatrutide Dosage Retatrutide was also used weekly in clinical trials, but final dosage recommendations are still under review

The FDA significantly increased its compliance activity surrounding advertising for compounded drugs in 2025, and recent remarks from an FDA official highlighted the agencys concerns about claims that state or imply the equivalence of compounded drugs to approved drugs.

As fatty liver disease continues to drive downstream costs, this signal is getting serious attention

At the highest dose, participants saw an average 11.2% weight loss, with 36% losing at least 15% and 18% losing at least 20% of their body weight