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Understanding this distinction is essential for setting appropriate patient expectations regarding how these medications facilitate weight reduction

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For example, a study showed that recombinant GLP-1RA improved endothelial function in patients with type 2 diabetes [5], while another study showed that exenatide increases the plasma concentrations of a number of vasodilators and suppresses the renin-angiotensin system [6]

The entero-endocrine-osseous axis involves gastrointestinal substrates for DPP-4, including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptides 1 (GLP-1) and 2 (GLP-2)