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162,163 In addition, contrary to predicted increases based on the Randle hypothesis, elevated free fatty acid levels were associated with reduced intracellular G6P levels in acute lipid-induced IR and type 2 diabetics

The choice between formulations depends on provider discretion and patient eligibility

A trailblazer in this field is semaglutide, the first GLP-1 receptor agonist approved for weight loss and type 2 diabetes management, marking a transformative step in peptide therapy innovation

doi: 10.1016/S0021-9258(18)68261-4 141 GkeRLarsenPJMikkelsenJDSheikhSP

Bridging the gap between diabetes and cardiovascular disease: a comparative review of different glucagon-like peptide-1 (GLP-1) agonists: efficacy, safety, and patient outcomes