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The Evolution of Peptide Therapy Semaglutide : A single-agonist (GLP-1) that changed the landscape of appetite control

This evaluation focuses on a Phase II clinical trial that tested the use of tesofensine in overweight individuals

Clin Diabetes (2014) 32:3243

Your three non-negotiables for muscle preservation: High protein intake 1.6-2.2 g/kg body weight daily, every single day Consistent resistance training 2-4 sessions weekly with progressive overload Reasonable weight loss pace 0.5-1% body weight per week maximum Do these three things consistently, and you'll preserve the vast majority of your muscle mass while losing fat