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Data correspond to usage on the plateform after 2015

J Neurol Neurosurg Psychiatry 89(10):10881100 Mollan SP et al (2019) The expanding burden of idiopathic intracranial hypertension

Why Traditional Site Selection Struggles Historically, site selection has relied heavily on: investigator networks CRO feasibility surveys historical trial relationships But these approaches often concentrate trials around the same academic institutions and urban research centers

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41,47 From a bioenergetics point of view, islet beta-cells are unique, as their intracellular ATP/ADP ratio is regulated by ATP supply and not ATP demand like in most other cell types
Because dose response can vary in this environment, dosing strategies such as microdosing are sometimes discussed as ways to adjust medication exposure
