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Description
Semaglutide, taken weekly, offers greater weight loss and blood-sugar improvement but can trigger stronger GI symptoms during dose escalation

However, in clinical practice, healthcare providers may find it challenging to adjust the dose of each drug in combination to achieve optimal glucose control while avoiding side effects, hindering the practical application of combination therapy
[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Garber AJ, Abrahamson MJ, Barzilay JI, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Desai A., Khataniar H., Hashash J.G., Farraye F.A., Regueiro M., Kochhar G.S
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Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetite