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At the same time as these investigations were happening, similar work was being undertaken by Ole Dragsbk Madsen, a Danish scientist working thirty minutes away at Novo Nordisk's Hagedorn Research Institute

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Because the two peptides hit two separate receptors that both feed the same GH pulse, they are described in research as synergistic rather than additive: GHRH-driven and secretagogue-driven signals combine at the pituitary

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The brain regions involved include the hypothalamus, hippocampus, and brainstem, which express GLP-1 receptors