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Slowing a degenerative cascade requires altering pathology over years, often after enough neuronal loss that the clinical trajectory is already set

Those with less responsive variants benefit from earlier escalation to higher doses or combination therapy, avoiding wasted months on subtherapeutic regimens

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GLP-1 and GIP/GLP-1 RAs Pipeline Source: clinicaltrials.gov Value Differentiation and Connection to Coverage New entrants to this crowded market will need to differentiate themselves through a strong payer value story that spans beyond T2D, overweight/obesity, CVD indications