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Semaglutide is the active ingredient in certain branded medications, including Wegovy and Ozempic

Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked

Learn FDA-approved injection sites, proper placement techniques, and expert guidance on administering GLP-1 receptor agonists safely and effectively.

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In a newly published study with Elisabetta Patorno and colleagues, we examined severe motility-related GI events, including gastroparesis, gastrointestinal obstruction, and severe constipation requiring hospitalization, among adults with type 2 diabetes initiating GLP-1 RAs vs SGLT-2 inhibitors