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2023;330(7):p

Another reason for the overall enhanced effect of GLP-1 and its analogs on feeding behavior in females is the ability of these substances to synergistically interact with estrogens

The ACHIEVE-1 trial involved 559 adult participants treated with orforglipron at 3 mg, 12 mg, or 36 mg, compared to placebo, over a 40-week duration

there isnt enough data yet, experts point out

However, 'legitimate' doesn't automatically mean 'high quality' or 'FDA-compliant' in the way most patients assume

!Safety note The FDA has reviewed reports of suicidal thoughts or actions with GLP-1 receptor agonists and, in 2026, requested removal of suicidal ideation and behavior warning language from affected GLP-1 labels after finding no increased risk