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These compounds have similar amino acid sequences compared to endogenous GLP-1, with small alterations, a free fatty acid side chain that binds to albumin, explicitly seen in liraglutide and semaglutide, that alter their pharmacokinetic properties (e.g., increased half-life and duration of action) [3]

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After several setbacks and challenges, researchers, including Knudsen, developed improved, next-generation GLP-1 drugs

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