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Circulating FGF-21 has also been implicated in energy expenditure effects with chronic glucagon agonism, as Fgf21 -/- knock-out mice are protected from these effects (57)

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10.1073/pnas.84.20.7005

Studies in animal models have shown an anorexigenic action of GIP receptor agonism [36] and a recent phase 1 clinical trial with a long-acting GIP RA found that repeated dosing for 4 weeks induced modest WL (1.9 to 3.1 kg vs