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The proposed mechanism: the leucine substitution increases hydrophobicity, potentially stabilizing the signal peptide and improving receptor trafficking to the cell surface meaning more receptor, more drug response

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Background Glucagon-like peptide-1 receptor agonists (GLP-1RA) have cardiovascular benefits in type 2 diabetes, but none of the cardiovascular trials studied atrial fibrillation/atrial flutter (AF) as a primary endpoint
