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It seems a subset of individuals who dont need or want to lose that much weight have turned to microdosing, which involves taking lower or less frequent doses of these drugs to lose smaller amounts of weightan approach unsubstantiated by clinical data at this point but nonetheless rapidly growing in popularity

GIP receptor activation enhances insulin secretion, modulates adipose tissue metabolism, and appears to synergise with GLP-1 activity to produce greater metabolic effects than either hormone alone as demonstrated by the clinical performance of the dual agonist tirzepatide

Users guide to mechanism of action and clinical use of GLP-1 receptor agonists

Research indicates that many addictive substances acutely increase dopamine signaling, although addiction also involves broader neurochemical, stress, learning, genetic, and environmental mechanisms