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These agonists stimulate the AMPK pathway, leading to the activation of Sirtuin 1 (SIRT1), a NAD + -dependent deacetylase that upregulates the expression of lipolytic proteins like triacylglycerol lipase

Patients with type 2 diabetes require careful planning to maintain glycaemic control if GLP-1 therapy is adjusted, with typical perioperative glucose targets of 6-10 mmol/L

Kumar explained that GLP-1 drugs dont permanently change the body

The starting dose is typically low and increases every few weeks until the target dose is reached