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PMID: 26109781

Applications of SEMAGLUTIDE: Type 2 Diabetes Management: Improves glycemic control
Methods In the PIONEER trials, people with type 2 diabetes were randomised to orally administered semaglutide versus placebo (PIONEER 1, 4, 5 and 8), empagliflozin (PIONEER 2), sitagliptin (PIONEER 3) and liraglutide (PIONEER 4) for 2678 weeks

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GLP-1 drugs curb appetite, but raise protein needs

Tirzepatide targets both GIP and GLP-1 receptors, producing 20-22% body weight loss in important trials
