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The goal here was to use combinatorial chemistry to create single molecules with multi-receptor potency comparable to the native incretins that might produce large effect sizes in preclinical studies such that effects were likely to be translatable to humans

It pushes the boundaries of what we thought was possible

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Our finding may just merit extra caution in the consideration between doctors and patients about who might use this medicine. Dr

For example, research has shown that the GLP-1 receptor agonist liraglutide can alleviate pain hypersensitivity in chronic migraine models by stimulating interleukin-10, suggesting its potential to modulate central sensitizationa crucial mechanism in chronic pain 62

Listen to your body and watch for signs that youre ready for a change