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Our study followed the target trial emulation framework, incorporating eligibility criteria, treatment strategies, assignment procedures, follow-up period, outcome, causal contrasts, and analysis plan aligned with an ideal randomized controlled trial, which we then emulated using observational data (Table S1)

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This estimate does not include rebates, which Medicares actuaries estimated to be 31.5% overall in 2022 but could be as high as 69% for Ozempic, according to one estimate

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Tirzepatide came off the FDA shortage list in December 2024 (enforcement discretion ended March 2025)

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In the fourth quarter alone, Mounjaros sales increased 60% year-over-year to $3.53 billion, significantly contributing to Lillys record total quarterly revenue of $13.53 billion, a 45% increase over Q4 2023

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States create a Preferred Drug List that ranks medications by preference

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Available online: 40.National Center for Health Statistics Heart Disease and Cancer among Adults Aged 18 and over, by Sex and Age: United States, 20082018: Figure 012

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