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Our study followed the target trial emulation framework, incorporating eligibility criteria, treatment strategies, assignment procedures, follow-up period, outcome, causal contrasts, and analysis plan aligned with an ideal randomized controlled trial, which we then emulated using observational data (Table S1)

This estimate does not include rebates, which Medicares actuaries estimated to be 31.5% overall in 2022 but could be as high as 69% for Ozempic, according to one estimate

Tirzepatide came off the FDA shortage list in December 2024 (enforcement discretion ended March 2025)

In the fourth quarter alone, Mounjaros sales increased 60% year-over-year to $3.53 billion, significantly contributing to Lillys record total quarterly revenue of $13.53 billion, a 45% increase over Q4 2023

States create a Preferred Drug List that ranks medications by preference

Available online: 40.National Center for Health Statistics Heart Disease and Cancer among Adults Aged 18 and over, by Sex and Age: United States, 20082018: Figure 012
