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Currently recommended pharmacotherapies in the practice guidelines from US, Europe, and Japan Evidence-based practice guidelines for the management of NASH/NAFLD were published by the American Association for the Study of Liver Disease (AASLD) in 2012 [5], the Japan Society of Gastroenterology (JSG)Japan Society of Hepatology (JSH) in 2014 [6], and the European Association for the Study of the Liver (EASD)European Association for the Study of Diabetes (EASL)European Association for the Study of Obesity (EASO) in 2016 [7]

Tirzepatide: Even greater, with average weight loss of 15-22% depending on dose

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In this study, obese men underwent an initial 8-week low-calorie diet (very low calorie, ~800 kcal/day), losing on average 16.5 kg (about 15% of body weight) pubmed.ncbi.nlm.nih.gov