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GLP-1R agonism promotes thermogenesis and increases Ucp1 expression in the brown adipose tissue (23), though the effect of leptin on thermogenesis is still debatable (2427)

The advancement of biosimilars and more economical production techniques may alleviate these issues

Next, the Lasker Foundation offers a different reading of the case [64], presenting its 2024 Lasker-DeBakey Clinical Medical Award to Mojsov, Habener, and Lotte Bjerre Knudsen (Novo Nordisk, leader of the translational work that turned GLP-1 into clinically viable products)

Antidiabetogenic Effect of Glucagon-like Peptide-1 (736)amide in normal subjects and patients with diabetes mellitus

16 The method accounts for crosstrial differences by measuring treatment effects relative to a common comparator arm and requires only the availability of summarylevel data for each trial

The growing influence of GLP-1 therapies may be a catalyst for some of those shifts