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This study published in the Annals of the Rheumatic Diseases indicates that GLP-1 receptor agonists might be disease-modifying for knee OA patients with comorbid T2DM, possibly mediated by weight loss, Lane said

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Therefore, intrinsic cardiac load and capacity do not improve in patients with heart failure with reduced ejection fraction, and patients HFpEF benefit only from the treatment of abnormal metabolism and inflammation

10.1016/j.yfrne.2021.100916 Front

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The agents are administered once weekly and once daily, respectively