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This Phase 1 trial, completed on an accelerated timeline, marks a key milestone in validating both the safety and translational potential of Hanmis next generation triple agonist in humans.Based on these results, Hanmi plans to initiate Phase 2 clinical trials in the second half of 2025, evaluating the long-term effects of HM15275 in reducing body weight and preserving lean mass in patients with severe obesity
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In this article we review the most relevant data exploring the mechanisms involved in the effects of GLP-1RAs in the brainadipocyte axis.
