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These medications work by mimicking a hormone called GLP-1, which is naturally produced in our gut

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Psychoneuroendocrinology, 37 (8), 1277

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Indeed, amitriptyline and imipramine (which are metabolized to nortriptyline and desipramine respectively) potently inhibit this response, as does nortriptyline itself, maproptiline, clomipramine (which is metabolized to the potent NE reuptake inhibitor desmethyl-clomipramine), and the nontricyclic NE reuptake inhibitors tomoxetine (now denoted atomoxetine) and reboxetine (Gobbi et al., 2003
B.et al (2008)
