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More companies are incorporating these medications into their treatment programs, but given that this is a new landscape with both proven and emerging uses, companies must measure vital signs, monitor secondary effects, and integrate behavior change into their care plans as they transition patients off these drugs over time

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Hormonal alterations, including reduced gonadal, thyroidal, and somatotropic activity, further impair bone formation and promote catabolism of lean tissues, including bone

Of these, glucagon-like peptide-1 receptor agonists (GLP-1RA) are incretin mimetics that have been shown to reduce HbA1c while inducing substantial weight loss with a low risk of hypoglycaemia [11]

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