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BMI 32.2 5.5 kg/m) allocated into three groups according to body adiposity and glucose homeostasis, as follows: normoglycemic eutrophic controls (CON, n = 11), normoglycemic with obesity (NOB, n = 15), and dysglycemic with obesity (DOB, n = 15)

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MHRA-licensed options include semaglutide (Wegovy), liraglutide (Saxenda), orlistat, and tirzepatide (Mounjaro)

The GLP-1R is a class B1 G protein-coupled receptor (GPCR) that mediates its effects via coupling to heterotrimeric G proteins 1