injection site itching tirzepatide reaction : r/tirzepatidecompound How to Inject Tirzepatide (Zepbound/Mounjaro):

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GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

Off-label and only under medical supervision

Drug-Related Gastroenteritis and Chemical-Related Gastroenteritis