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The optimized semaglutide-loaded DPI, composed of semaglutide, mannitol, coarse lactose, fine lactose, and magnesium stearate at a weight ratio of 0.71:2.0:2.203:0.55:0.037, achieved a fine particle mass (FPM) of 36.9% of the total semaglutide, representing the fraction of particles with an aerodynamic diameter smaller than 5 m suitable for deep lung deposition

After this window, even refrigerated pens should be discarded due to potential contamination and reduced peptide stability

[DOI] [PubMed] [Google Scholar] 244.Poynter ME, Daynes RA

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This mechanical effect is independent of whether the soda is regular or diet