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(68), which reported that sweet taste receptor antagonism with lactisole reduced GLP-1 and PYY secretion but had no effect on CCK release, highlighting pathway-specific effects

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Severe nausea on GLP-1 medications combined with illness-related vomiting creates a dangerous situation where: Dehydration can develop rapidly You cannot absorb oral medications or nutrients The GLP-1 medication may worsen gastrointestinal symptoms Risk of electrolyte imbalances increases When to seek emergency care : If you cannot keep any fluids down for 12+ hours, notice dark urine, feel dizzy upon standing, or have a rapid heartbeat, seek medical attention immediately

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Side Effects The most common side effects of GLP-1 receptor agonists include nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during the initial dose escalation

J Hepatol (2015) 62:S4764