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In both -cells and intestinal L-cells, Gcg expression is controlled by certain homeodomain proteins [94,98,100] and by cAMP-activation of protein kinase A (PKA), as demonstrated in primary rat intestinal cultures [126], isolated pancreatic cell lines [127,128] and enteroendocrine GLUTag and STC-1 cell lines [129,130]

Genetically predicted lower HbA1c and lower BMI via GLP-1R activation yielded point estimates consistent with lower coronary artery disease risk and lower parental mortality, a proxy for all-cause mortality, although the confidence intervals were wide

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