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Main Analysis of Semaglutide OW Comparative Effectiveness with SGLT2is The subset of patients initiating semaglutide OW who did not have baseline or follow-up use of SGLT2i were identified, characterized, and compared with patients initiating SGLT2i after inverse probability of treatment weighting (IPTW), for changes in weight, BMI, HbA1c, composite weight and HbA1c outcomes, all-cause HCRU, and medical costs

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MS is a chronic autoimmune disorder with significant individual and societal impacts

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Further delineation of the mechanisms underlying alpha-cell GLP-1 production is needed to fully characterize this intra-islet paracrine feedback loop