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Injectable GLP-1 and dual agonists command 78.4% of total drug revenue

GLP-1 plays a crucial role in regulating several physiological and metabolic functions, including appetite, satiety, glucose and insulin balance, GI motility, liver fat metabolism, and even bone remodeling (1)

In 2009, another GLP-1 agonist, liraglutide, reached the market, followed by the establishment of more GLP-1 agonists in diabetes management [7]

Modern advances in long-acting peptide design, biased agonism, receptor de-orphanization, and systems pharmacology fundamentally alter the riskbenefit calculus of these targets

For patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis, the ESSENCE data support semaglutide 2.4 mg

Its estimated that half of the U.S