setmelanotide vs semaglutide Anti-obesity Medications and Muscle Loss A small study presented at ENDO 2025 suggested taking the anti-obesity medication can raise the risk of muscle loss. Researcher Melanie Haines, MD, discussed the findings Aqueous remote loading of setmelanotide

Eating smaller, more frequent meals helps

Gallbladder disease: Risk exists throughout treatment, not increasing over time Pancreatitis: Rare, not clearly time-dependent Muscle mass: Long-term weight loss may affect muscle

In the SURPASS-2 trial, tirzepatide did not cause relevant changes in mean calcitonin levels

BMJ 342 , d1165 (2011)

Semaglutide works by suppressing appetite, but side effects such as muscle loss, nausea, and diarrhea have been reported, and it's common to regain the weight after stopping treatment

SGLT2 inhibitors increase urinary glucose and water excretion and can precipitate euglycemic diabetic ketoacidosis, which may present with thirst, nausea, and vomiting even when blood glucose levels are not severely elevated