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Short half-life, pleiotropy, and behavioral or cardiovascular effects were historically interpreted as disqualifying features

Very interesting work showing direct GLP-1R effects beyond weight loss.It is close to my interest Congratulations for this important work

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9 Approved in 2005, exenatide was the first GLP-1 drug to be made available, and later modifications allowed for its extended release

Moreover, these GLP-1R polymorphisms are associated with higher breath concentrations of alcohol and increased intravenous infusion of alcohol in social drinkers (Suchankova et al., 2015)

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